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Genesis Lifestyle Medicine Blog | Top 3 Medical Weight Loss Drugs Worth Considering

Navigating the challenging journey of weight loss requires a comprehensive approach. At Genesis Lifestyle Medicine, we advocate for a holistic methodology, blending lifestyle modifications, physical activity, mental wellness, and in some cases, medically-supervised weight loss treatments. For those struggling to shed weight through diet and exercise alone, several FDA-approved prescription medications can provide an additional boost. Among these, Mounjaro, Semaglutide, and Phentermine stand out due to their efficacy and manageable side effect profiles. This article explores these top three medical weight loss drugs.



Mounjaro, also known by its generic name tirzepatide, is a weight loss medication developed by Novo Nordisk, a Danish pharmaceutical company. It is a GLP-1 receptor agonist that stimulates insulin release in response to high blood glucose levels. This helps to regulate appetite, reduce hunger, decrease food intake, and promote feelings of fullness. Mounjaro targets the hormones responsible for hunger and satiety, making it easier for individuals to adhere to dietary changes and achieve weight loss goals.
The Scientific Mechanism
Mounjaro functions as a GLP-1 receptor agonist, acting on the glucagon-like peptide-1 (GLP-1) receptors in the body. When Mounjaro binds to these receptors, it stimulates the release of insulin and glucagon, hormones involved in regulating blood sugar levels. Additionally, Mounjaro affects appetite and satiety by targeting the brain's regions responsible for hunger and food intake, decreasing food cravings and increasing feelings of fullness. These combined effects of Mounjaro contribute to reduced calorie intake, promoting weight loss.
Efficacy & Results
Clinical trials have demonstrated the remarkable efficacy of Mounjaro (tirzepatide) in promoting weight loss. When used with a reduced-calorie diet and increased physical activity, Mounjaro has been shown to help individuals significantly reduce body fat and weight. In fact, participants in clinical trials experienced an average weight loss of up to 21% of their initial body weight, surpassing those who received a placebo. Besides weight loss, Mounjaro improves metabolic rate, enhances fat burning, and improves blood sugar levels.


Semaglutide is a weight loss medication that imitates the action of the glucagon-like peptide-1 (GLP-1) hormone. It is administered via intravenous injection once a week during the course of treatment. GLP-1 plays a crucial role in controlling blood sugar and weight. By acting on specific receptors in the brain, Semaglutide suppresses appetite and delays stomach emptying, leading to increased feelings of fullness. This medication has been approved by the FDA after rigorous clinical trials and has shown significant effectiveness in promoting weight loss.
The Scientific Mechanism
Semaglutide, as a GLP-1 receptor agonist, operates by mimicking the action of the natural GLP-1 hormone in the body. When administered, Semaglutide binds to GLP-1 receptors, particularly in the brain, and activates them. This activation leads to several physiological effects, including appetite suppression and the delay of stomach emptying. By affecting the brain's areas responsible for hunger and food intake, Semaglutide helps individuals feel fuller for longer periods, reducing calorie intake. Additionally, it aids in regulating blood sugar levels and may contribute to weight loss by promoting a calorie deficit.
Efficacy & Results
Semaglutide has shown impressive efficacy in promoting weight loss. Clinical trials have demonstrated that individuals using Semaglutide experienced substantial reductions in body weight. In a study spanning 68 weeks, participants receiving Semaglutide lost an average of 14.9% of their initial body weight, surpassing those who received a placebo. These findings highlight the effectiveness of Semaglutide in aiding weight loss efforts. Furthermore, Semaglutide has been shown to improve glycemic control and other metabolic parameters, making it a valuable option for individuals seeking successful weight management.


    Phentermine is a weight loss medication that has been approved for long-term use. Phentermine works by affecting the brain and nervous system, specifically by increasing the release of neurotransmitters dopamine and norepinephrine. This leads to an increase in metabolism and suppression of appetite. Phentermine also triggers the release of adrenaline and epinephrine, hormones known for their fat-burning properties. It is a safe and non-addictive medication with a high success rate when used properly.
    The Scientific Mechanism
    Phentermine acts as a sympathomimetic amine, working primarily in the brain and nervous system. It stimulates the release of neurotransmitters, such as dopamine and norepinephrine, which play essential roles in regulating appetite and metabolism. By increasing the release of these neurotransmitters, phentermine stimulates the central nervous system, suppressing appetite and promoting a sense of fullness. Furthermore, phentermine triggers the release of hormones like adrenaline and epinephrine, which enhance metabolism and promote fat burning. These mechanisms collectively contribute to the weight loss effects of phentermine.
    Efficacy & Results
    Phentermine has demonstrated notable efficacy in weight loss. When used with a suitable dietary strategy, phentermine has shown significant results. Studies have indicated that taking 37.5mg of phentermine daily for 12 weeks leads to an average weight loss of around 16 pounds. The medication works by suppressing appetite and stimulating metabolism by releasing neurotransmitters and hormones. While phentermine is not a standalone solution, when combined with a healthy lifestyle, it can contribute to successful weight loss.

    The Genesis Lifestyle Medicine Approach

    At Genesis Lifestyle Medicine, we understand that each patient's journey to weight loss is unique. While medications like Mounjaro, Semaglutide, and Phentermine can be effective, they must be prescribed as part of a comprehensive weight management plan. This includes dietary changes, exercise, counseling, and in some cases, medications.

    As the field of obesity medicine continues to evolve, so too do our treatment plans. We are committed to offering the most innovative, safe, and effective treatments to help our patients achieve their weight loss goals. Remember, the journey towards a healthier life starts with a single step, and Genesis Lifestyle Medicine is here to guide you every step of the way.

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